The hosts only needed eight minutes to open the scoring, when Corentin Tolisso reacted quickest to bury the loose ball after Palace failed to cope with a corner from the right. In a quiet first half, Lyon doubled their lead in injury time as Ernest Nuamah finished well from Keito Nakamura's low cross. Palace had come from behind to gain Premier League wins over Fulham and Nottingham Forest this season and were much improved after the break, finding a way back into the match in the 50th minute. The visitors worked a short corner, with Adam Wharton's fine first-time pass instantly met by Yeremy Pino before he shot into the roof of the net to make it 2-1. Palace had chances to make it 2-2 before Lyon restored their two-goal advantage thanks to Pavel Sulc's clever backheel flick into the net. Daichi Kamada gave Palace hope as he finished from six yards out to make it 3-2, but the hosts held on for the victory. It was a return to Lyon for Eagles boss Pierre Sage, who had been manager of the Ligue 1 club from November 2023 to January 2025, having previously been a coach. Palace won the third-tier Conference League last season and this is their first campaign playing in Europe's second-tier competition. After two of their eight league-phase matches, they have three points following the 4-0 win over Polish side Lech Poznan.

Goals from Gabri Veiga and Samu Aghehowa turned the game in Porto's favour after Abde Ezzalzouli gave Betis the lead, before Betis striker Cucho Hernandez dragged the hosts level and Isco converted from the penalty spot. Real Betis dominated the first-half chances, but it was Porto who felt they should have gone into half-time with a lead - Martim Fernandes' strike from close range was ruled out after a video assistant referee check because of a handball by Borja Sainz in the build-up. The second half exploded into life after 80 seconds when Betis winger Ezzalzouli produced a stunning curling effort from the edge of the penalty area. Former Manchester United winger Antony should have doubled the hosts' lead when he hit the post two minutes later after pouncing on a loose ball, and Betis were soon made to pay. Seven minutes after going behind, Porto midfielder Veiga curled a free-kick past Betis goalkeeper Alvaro Valles from 25 yards out. Seven minutes later, half-time introduction Aghehowa ran on to a cute Pepe backheel and rifled in off the underside of the crossbar to complete the Porto turnaround and cap a frantic start to the second half. Betis looked at risk of crumbling, but to their credit regrouped and drew level when substitute Hernandez converted from an Antony cutback 12 minutes after replacing the ineffective Troy Parrott. The Spanish side were awarded a penalty in the 83rd minute after a video assistant referee check spotted a trip on Angel Ortiz, and captain Isco slotted into the bottom corner. This is Betis' second home win in Champions League history, the first coming against Chelsea in November 2005. Next up for Betis is a home meeting with Feyenoord on Wednesday, 21 October (20:00 BST), while Porto will host PSV Eindhoven on Tuesday, 20 October (20:00 BST).

Mourinho guided Roma to the Conference League title in 2021-22 and then to the Europa League final the following season, with the home fans producing a number of banners celebrating their former boss. But Mourinho's current side Real looked to be heading for defeat when they fell two goals behind in the 83rd minute. However, substitutes Carlos Espi and Endrick scored to make it 3-3 before Antonio Rudiger converted a dramatic close-range 90th-minute winner. Mourinho's changes proved crucial as Roma could not cope with corners from another substitute, Arda Guler, and crumbled late on. Espi scored five minutes after coming on when he converted a rebound after Endrick's header had been parried. The Brazil forwarded then headed in from Guler's corner before Rudiger steered in another Guler set-piece with a close-range volley. It was a remarkable finish to a thrilling match. The hosts had taken a deserved lead in the 20th minute when Marten de Roon produced a first-time 20-yard shot from Matias Soule's pass. However, Real were only behind for five minutes. Kylian Mbappe, making his 100th Champions League appearance, saw his strike take a deflection off Gianluca Mancini with the ball looping up and over goalkeeper Pierluigi Gollini for his 72nd goal in the competition.

Nicolas Jackson's double and Johan Manzambi's opener put the hosts in control before the break in front of the watching Prince of Wales. Ross Barkley's struck a second-half penalty and netted a deflected effort to put the gloss on a result before Tammy Abraham's late goal sealed Villa's biggest European victory. Victory at home to Viking next week would put Unai Emery's side on course to qualify from the league phase, having already beaten Club Brugge in their European opener. Manzambi celebrated his 21st birthday when his deflected effort wrong-footed Ederson and dropped in after 12 minutes and Jackson doubled the lead with a low finish 19 minutes later. Villa needed Zion Suzuki to save twice from Vedat Muriqi and he tipped Oguz Aydin's strike on to the bar but the poor visitors were too fragile in defence. Jackson added a second before the break, seizing on slack defending after Barkley won the ball on the edge of the area, to score his fourth goal in three games. The striker was denied a hat-trick when Barkley scored from the spot with 22 minutes left after Manzambi was tripped by Ismail Yuksek. Barkley then added a fifth when his strike from the edge of the box was deflected in and Abraham tapped in late to complete the thrashing.

City – watched by former manager Pep Guardiola on his return to the club – were playing their first home game since being found guilty of breaching Premier League financial rules. In an atmosphere of defiance from City's supporters, PSG stunned Enzo Maresca's side by powering into a three-goal lead by half-time. Desire Doue opened the scoring in the 13th minute with a low shot past City keeper Gianluigi Donnarumma, before setting up the second with a perfect cross for Ousmane Dembele's header two minutes later. PSG were tearing City apart, Vitinha adding the third after 32 minutes with a clinical finish after superb link play between Maghnes Akliouche and Warren Zaire-Emery. Maresca made three half-time substitutions and City were a team transformed after the break, creating a host of chances before Erling Haaland pulled a goal back with a flicked header from Iliman Ndiaye's cross eight minutes after the interval. City's hopes of a comeback were stopped in their tracks after 62 minutes when Donnarumma initially saved Akliouche's shot, only for it to drop behind him into the net. City refused to yield, Haaland getting his second and seeing another effort miraculously kept out by PSG keeper Matvei Safonov - the one final act of drama coming when Donnarumma saved Ferran Torres' late penalty.